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Finally, nominating genes that act through gene expression also presents an obvious weakness, by missing gene variants that cause null or poorly trafficked proteins, for example.
Protein trafficking to the cell surface may be more efficient in some cells than in others, or perhaps the rapid rate of ENCDC division does not permit the accumulation of poorly trafficked, but hyperactive, protein.
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Depending on the type of transport, these can be heavy traffic, poorly synchronized traffic lights, and passenger behaviors.
As reported previously [ 15] Kv4.2, when expressed alone, trafficked poorly to the plasma membrane and accumulated in the Golgi complex.
A side-effect of the rapid growth of China's road network has been a significant rise in traffic accidents, with poorly enforced traffic laws cited as a possible cause in 2011 alone, around 62,000 Chinese died in road accidents.
When accessing the circuit by car, there can be long lines of poorly regulated traffic.
The new law is a major step forward, but because of low public trust in poorly paid traffic cops, who can often be seen taking money from road users for the slightest infraction, it risks the fate of other forward-thinking legislation in Cambodia: good on paper, useless in reality.
In hepatocytes, FA are taken up by transporters [ 45], followed by poorly defined trafficking of FA to target organelles such as mitochondria and peroxisomes to undergo oxidation.
Despite the fundamental importance of the process, the mechanisms by which cargos are trafficked along microtubules are poorly understood.
Exosomes originate within endosomes and are trafficked to the plasma membrane by a poorly understood pathway (Raposo and Stoorvogel, 2013).
Experts attribute the accidents to a deadly combination of bad roads, chaotic traffic, poorly enforced safeguards, badly trained bus drivers and a lack of political will to address the problem.
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