However, the genetic basis of desired domestication traits is poorly understood because robust genetic tools do not exist for industrial hosts.
Patients with NSCLC are at an increased risk of PH owing to the underlying disease process, although the pathophysiological mechanisms are poorly understood and robust data on the background incidence of clinically significant and severe PH are lacking.
In fact, we have not found real or simulated data for which the Wald test performed poorly for the Robust Poisson method, but we have found (but not presented) such data for the log-binomial method.
The combined efforts of academia and industry were able to overcome numerous substantial challenges: the target was not yet validated in vivo, the viral lifecycle was poorly understood, no robust preclinical models in cell culture or animals were available, and no structure of the viral protease had been solved.
During precise model verification some of them were found non-robust or poorly converging and replaced by more robust solutions, demonstrated in the paper.
Based on the experimental results above, we have come to the conclusion that our greedy algorithm overall has a higher accuracy than L1 minimization and SBL with a comparable efficiency, though OMP may be less robust in poorly illuminated regions.
Alternatively, infection might indirectly induce ALL by stimulating an overly robust or poorly regulated immune response that would otherwise be protective.
In contrast, this F1−V vaccine protected African green vervets poorly despite eliciting a robust antibody response, although a fusion F1-V with a potent adjuvant flagellin likely can provide better protection in this and the cynomolgus macaque model.
Areas where studies seemed to perform poorly were: performing a robust analysis of uncertainty (Q5, four studies), inclusion of all major short-term and long-term maternal and fetal outcomes (Q10, no studies), and incorporation of a time horizon that included the effects within-pregnancy and lifetime for the mother and infant (Q8, one study).
Such robust views meld poorly with the concept of a patient-centered approach.
