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They found higher levels of activated STAT1, STAT3, and STAT5 in lymphoma cell lines that poorly responded to Vorinostat treatment compared to sensitive cell lines.
In all six patients, their respiratory conditions progressively deteriorated despite discontinuation of MTX, and they poorly responded to high-dose corticosteroid.
Notably, combination with DARA seemed to improve MM cell lysis especially in the samples that poorly responded to LEN and BORT MMM cell lysis <30% Figure 1a).
Interestingly, NTHi treatment of HMEEC resulted in the up-regulation of β-defensin 2 while Hela and A549 cells poorly responded.
More importantly, our clinical data showed that tumors with high Ubc9 expression poorly responded to neoadjuvant chemotherapy and experienced recurrence and metastasis more rapidly.
For the same reason, ABC type is expected to represent the majority of patients who have poorly responded to salvage chemotherapy like R-DHAP or R-ICE as shown prospectively in the CORAL study [ 12].
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This is important since cancers poorly responding to conventional chemotherapy are also poor responders to BH3 mimetics, as both responses depend on the "mitochondrial apoptotic priming" status [ 5].
However, in some patients headaches poorly respond to drug treatment, especially in chronic courses of disease.
In support of this hypothesis are findings that depressed patients suffering from psychotic symptoms poorly respond to rTMS.
Urine output is traditionally regarded as an index of organ perfusion, and it is reasonable to hypothesize that these poorly responding patients are at higher risk for fluid excess.
Therefore, timely use of CRRT in case of fluid overload that is poorly responding or refractory to diuretics might be a reasonable approach to attenuate or control SAKI [40].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com