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However, such studies may be poorly powered to assess the incidence of uncommon adverse events (AEs) [ 2], which may be complicated further by inconsistent reporting practices [ 3, 4].
The I statistic is preferable to the test for heterogeneity [ 15, 16], which is poorly powered with few studies to support its use [ 17].
Both trials demonstrated a significant improvement in progression-free survival; neither demonstrated an improvement in overall survival, though both were poorly powered.
Evidence to direct OI guidelines is partly limited by the fact that many large-scale studies date from the pre-ART era and more recent studies are sometimes poorly powered due to the falling rates of OI.
Results can be found by chance (winner's curse effect), more often in poorly powered studies [ 6], or be declared significant after too many variations of the analysis procedure [ 7, 8] without controlling appropriately for the overall risk of error (p-hacking effect [ 6, 9]).
In our view, including such studies does not make statistical sense and we suggest that meta-analyses more generally may benefit from the exclusion of such poorly powered studies from the outset.
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The only thing that should matter to outsiders is that Nicaragua remain a democracy, and that Mr Ortega, presuming he governs poorly, surrender power peacefully in five years' time.Chávez's meagre haulAs for Mr Chávez, he has gained another ally in the region.
For the control of rapid and poorly predicted power peaks / deviations it is also necessary to use large Nuclear Power Plants.
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