It is rooted in fundamental thermodynamic and dynamic properties of macromolecular systems that are still poorly understood and are moreover modulated by the cellular context.
<8 (better) >8 (poorly) 10.7 ± 5 16 better, 16 poorly, 19 control 51 1 100 Poor glycemic control negatively modulated the bone factors during healing, although diabetes (regardless of glycemic control) had no effect on implant stabilization.
Although it is acknowledged that genetic variation contributes to individual differences in thermotolerance, the specific genes and pathways involved and how they are modulated by the environment remain poorly understood.
This approach offers a platform technology for delayed release of potent but poorly soluble drugs and the release can be modulated by adjusting the film-coating composition and thickness and/or the cyclodextrin and pH modifier, if necessary.
DR activity can also be modulated by DR antagonists, which have been poorly characterized in the context of NBLs.
These authors concluded that R gene function is modulated in an organ-specific but mechanistically poorly defined manner for the purpose of suppressing HR in the roots.
We conclude that following human gaze into distant space in dogs is modulated by training, which may explain why dogs perform poorly in comparison to other species in this task.
However, TE dynamics among related taxa from natural populations and the role of TEs at the species or supra-species level, where genome size and karyotype evolution are modulated in concert with polyploidy and chromosomal rearrangements, remain poorly understood.
The signalling pathways that govern cell responses to 3O-C12 are poorly elucidated; the molecule modulates the activity of peroxisome proliferator-activated receptor-gamma (PPARγ) [31] but no specific receptor(s) and/or signalling pathway(s) have been identified as mediators of 3O-C12 cytokinductiontinduction
NF-κB signaling can be modulated by NSAIDs in experimental models but the exact mechanism is poorly understood [ 13, 14].
How are proliferation markers expression and distribution in the different cell cycle phases modulated in the different regions of a multicellular tumor spheroid remains poorly known.
