The PCPG is a network based on hierarchical clustering and it allows one to take into account the heterogeneity of interactions by keeping information in a hierarchical way, so that retaining information about also about poorly interacting groups of elements that could not be selected with a threshold method.
Using this approach, we found that the coiled coil regions of myosins V are generally interrupted by poorly interacting dimeric zones (Fig. 7B).
When DNA is damaged or genes interact poorly with one another, the eventual result is disease.
The liver can also be injured by taking two or more drugs that interact poorly.
Hospitalization is typically required for administration of hemin, and appropriate drug selection is key to avoid exacerbating symptoms with drugs that interact poorly with porphyrias.
Interestingly enough, the main bacterial chaperones, GroEL and DnaK, interact poorly with proteins smaller than 20 kDa and display a preference for larger substrates (Figure 5A) [62], [63], [63], suggesting the presence of redundant mechanisms to reduce the aggregation propensity of long bacterial proteins, as previously described for the human proteome [21].
Whereas apolar molecules interact poorly with water and are readily bound through the hydrophobic effect, polar species and binding sites are well-hydrated.
At the most extreme end of the glycan array results are receptors that are known to bind sugar ligands but which interact poorly with all of the oligosaccharides on the array.
As cyclic-di-GMP-unbound LapD proteins interact poorly with LapG, this leaves some LapG molecules able to destabilize the attachments between the cells and the surface, which disperses the biofilm.
In vitro studies by these investigators found that VLDL from the APOC3 transgenic mice were lipolyzed normally by LpL but had reduced uptake into cells 6; this latter finding is what one would expect from nonlipolyzed TGRLs that interact poorly with lipoprotein receptors.
