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Tumor-targeted scFv-TRAIL fusion proteins can mimic the naturally membrane-bound form of the ligand enabling DR4- and particularly DR5-mediated apoptosis induction, which is poorly exerted by soluble forms of TRAIL.
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Notably, the forkhead O (FoxO) transcription factors play essential roles in preserving quiescence and enhancing survival of HSCs in the bone marrow through regulating the response to physiological oxidative stress (Tothova et al., 2007), although how this regulation is exerted remains poorly understood.
Although poorly studied, the social pressure exerted by families or bystander could influence the medical decision in different ways.
While the clinical efficacy of beta-blockers in reducing migraine attack frequency is certainly established [1 4], it is still poorly understood how they exert their therapeutic effect.
It is still poorly understood how Herceptin exerts its mechanism of action and how the acquired resistance to this drug occurs.
The metabolic impact exerted on a microorganism due to heterologous protein production is still poorly understood in Streptomyces lividans.
Memory, however, exerted a pull.
And power recklessly exerted has consequences.
Economic opportunity also exerted a strong pull.
Ekelöf exerted great influence on his contemporaries.
He exerted a calming influence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com