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However, butyrate and hemolysin assays are poorly established for permeability assessment so far.
A large body of evidence indicates that protein aggregation and proteotoxicity are central early pathogenic steps in these disorders, but how these events ultimately result in neuronal malfunction and degeneration is yet poorly established for most disorders [ 1, 2].
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These poorly established criteria for antibody selection and their impact on ADC activity make it difficult to design an optimized mAb.
Biomarkers which predict these fatal outcomes and provide insight into the pathogenesis are poorly established but highly required for an early risk stratification of this high risk cohort of patients [2], [3].
Unlike the obvious functions of PCD in multicellular organisms, the selective advantages of cell death program in single cells are poorly established, thus evolutionary selection for metacapases may be based on functions unrelated to cell death.
Among these, drying is especially suited for developing countries with poorly established low-temperature and thermal processing facilities.
Breast cancers may be associated with PCa, but whether this is true for other tumor types is poorly established.
For ease of comparison, we have combined responses 1, 2 as "poorly established"; 3 = neutral; 4, 5 combined as "well established".
Validated composite outcomes after complicated cardiac surgery are poorly established.
The competences to fund the commercialization of regenerative medicine are poorly established in Finland.
Students were then asked to rate how well established four such ideas are, using a five-point scale from 5 = well established to 1 = poorly established.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com