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Although this will not generally change specific characteristics for shake flask cultures such as the problem to establish specific pO2 levels and poorly controllable aeration of the cultures, the proposed solution is a way to control the physiological state of the cultures in early screening phases in a similar way as during later process development.
Cu is known to be a poorly controllable impurity, and its concentration in the subsurface layers of Si wafers which were not subjected to the gettering process may reach 1015 cm-3.
The patient died within 4 days of a systemic-inflammatory response syndrome primarily due to her superinfected, poorly controllable wounds.
The increase in major peri-operative bleeding with the GDWF technique might be explained by the poorly controllable dilation with the forceps [ 9].
This assay is sensitive but needs manipulation and disposal of hazardous radioactive reagents and provides a bulk estimate of the reporter released, which may be influenced by spontaneous release of the label and other poorly controllable variables.
In order to eliminate the poorly controllable collection efficiency parameter, ξ from Eq. (5), one needed to benchmark the ZnO TPIL signal against that of the tabulated fluorophore, such as Sb1.
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There is a problem of equal magnitude for poorly-managed controllable asthma resulting in persistence and deteriorating lung function.
(Controlling the controllable, Jop Groeneweg 2002).
However, the use of host cells produces noise and not controllable behaviors, leading to poorly robust systems.
"I can only control the controllables.
But you can only control the controllables.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com