This diagnostic time course contrasted with most other differentially expressed genes unrelated to the cell cycle and allowed us to screen among poorly characterised genes for novel players in cell replication like Fignl1 and G7e.
Here, we show that the poorly characterised protein Cep126 (for centrosomal protein of ∼126 kDa), previously known as KIAA1377, (Chen et al., 2009; Lim et al., 2012; Tipton et al., 2012) is a novel and fundamental regulator of centrosomal function.
Despite the veterinary importance of C. pseudotuberculosis, the bacterium is poorly characterised; therefore, effective treatments for caseous lymphadenitis have been difficult to establish.
In vitro and in vivo studies as well as some clinical trials provide some evidence mostly for phytochemically poorly characterised Hs extracts.
This wide consultation led to agreement to change FAM62, a temporary HGNC symbol for this poorly characterised gene family, to Esyt [ 67].
These variants, along with the poorly characterised p.Arg309Cys, were therefore selected for further investigation, and their sequences deposited in GenBank (accession numbers are listed in " Materials and methods").
Fodor et al. [ 3] using Human and Mouse Affymetrix Genechip arrays, hypothesised that poorly characterised variance and normalisation strategy for a microarray can produce a non-uniform distribution of P values for null genes (genes that are not differentially expressed between groups).
The identification of these poorly characterised genes and in-depth characterisation of their corresponding proteins may be important for the development of novel strategies to enhance resistance of cows to mastitis and the development of novel antibacterial therapeutic agents.
For genomes with poorly characterised repeat families, any similarity-based detection methodology needs to be complemented with de novo repeat discovery [[ 62- 65], for example].
An advantage of using, at least in the initial analysis, alleles that are globally expressed is that no assumptions are made about the tissues involved in a complex multiorgan disease such as type 2 diabetes; this is especially important for genes with poorly characterised or unknown function.
