Exact(2)
The results of the present study showed that lymphovascular invasion but not microvessel density was consistently associated with poorer recurrence- free and cancer-specific survival in both ER negative and ER positive tumours.
Accumulating evidence indicate that progressive tumour growth is dependent on angiogenesis [ 31] and several studies have reported an association between microvessel density and poorer recurrence- free [ 23, 32- 37], cancer- specific survival [ 16] and overall survival [ 16, 23, 32, 34, 35, 38].
Similar(58)
A high expression of phosphorylated Akt (pAkt-1) is associated with a poorer recurrence-free survival in prostate cancer [31], and it would clearly be of interest to investigate whether the expression of CB1 receptors is correlated with pAkt-1 in prostate tumour tissue obtained at diagnosis.
Patients with high soluble L1 concentrations had a poorer recurrence-free survival than patients with lower levels.
On multivariate survival analysis, tumour size (HR 5.30, 95% CI 1.79 15.71, P=0.003) was independently associated with poorer recurrence-free survival.
Poorer recurrence-free survival may result from delays in the initiation of adjuvant therapy or avoidance owing to prolonged patient recovery or ill health.
IBL > 4 L was significantly associated with a poorer recurrence-free survival (P < 0.001 for IBL > 4 L vs. ≤ 4 L, Fig. 2).
The Kaplan Meier survival estimation showed that patients with h TERT amplification by qPCR had poorer recurrence-free survival (log rank test P=0.02, Figure 2A).
Several recent studies have reported an association between higher Ki-67 proliferative activity and poorer recurrence-free [ 11- 13] and cancer-specific survival [ 14- 16].
More recently, study by Mahmoud et al (2012) reported that high CD68+ macrophage infiltrate was significantly associated with poorer recurrence-free and cancer-specific survival.
Patients with additional nodule by CTHA/CTAP showed significantly poorer recurrence-free survival than those without additional nodules (P=0.003, Figure 2c).
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