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It has been under investigation as a potential treatment for a variety of solid tumors although with much poorer efficacy than for APL.
In poorer efficacy subgroup, no benefit was seen with aflibercept.
By contrast, in the poorer efficacy subgroup, no benefit was seen with aflibercept.
Figure 3 shows a forest plot of overall survival for the better and poorer efficacy subgroups.
Figure 2B shows the OS for the poorer efficacy subgroup by treatment arms.
On the contrary, no improvements in PFS or ORR were observed with aflibercept in the poorer efficacy subgroup.
Similar(35)
It seems unlikely that there would be much interest in combining very efficacious PEV or BSV with a rather poor efficacy partner.
The drugs currently employed have limitations such as poor efficacy, drug resistance or side effects.
Failures of molecules in Phase III for poor efficacy raise questions about target identification and validation.
A key factor responsible for the poor specificity and poor efficacy of CAR-T against malignant epithelial cells is the lack of specific targetable antigens.
However, the main limitation of micro-CT lies in the poor efficacy or toxicity of the contrast agents.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com