These observations, further explored by means of molecular modeling, reveal the previously unrecognized unpredictability of the benefits of multivalency, possibly because of poor accessibility of the viral targets to polymeric agents.
To date a poor accessibility of the tumor mass and a hostile microenvironment, influenced by genetic and epigenetic instability, mainly limit ACT therapeutic efficacy in the case of solid tumors.
It may be deduced that its poor catalytic activity at low temperature is due to poor accessibility of MAO to chloride and, hence, less alkylation.
For the narrow spacing, the enhancement in capacitance is not so obvious, which could be ascribed to the poor accessibility of the interlayer by electrolyte ions.
Some stakeholders have also mentioned failings related to the deterioration of monitoring networks, inadequate communication of warnings by forecasters to end users, and poor accessibility of warning systems.
The high interactive effect of N and P on P uptake is an indication of the relatively poor accessibility of soil P which improved with greater soils exploitation due to better root growth.
Application to heavy oil, despite its higher sulfur content, is unpractical, due to the poor accessibility of large molecules in the narrow pores and steric hindrance that reduces adsorption effectiveness.
[16], [28], [33], [34] Secondly, the reason for only some of the tumor cells being positive for EBV expression could be because of low expression of protein in tumor cells or because of poor accessibility of the antibody to the antigenic site.
However, the poor accessibility of tumour tissue is a major obstacle for routine measurement.
It led to health inequality and poor accessibility of health services [ 5].
