Some typical neuroleptics are indicated in tics or in behaviour disorders associated to autism or related syndromes but present clinical limitations and poor tolerability.
At the moment, medical oncologists are still reluctant to use chemotherapy in elderly partly because of concern about increased toxicity and poor tolerability of this patient cohort, and the inability to appropriately select elderly that may benefit from chemotherapy.
In the case of the apicomplexan parasite Toxoplasma gondii, the need to find alternative treatments is imperative because of the poor tolerability and frequent side-effects associated with existing therapeutic strategies.
Poor tolerability for current acute or preventive treatments.
Poor tolerability to lithium is not rare, mainly in elderly patients.
Unfortunately, despite its efficacy, significant adverse effects and poor tolerability are not rare, mainly in elderly patients.
Poor tolerability was operationalized as an overall score at or above the 75th percentile using responses to questions adapted from a previously developed questionnaire.
The treatment of CH is challenging, and many of the commonly used abortive and preventive medications are associated with serious safety risks, poor tolerability, and/or marginal efficacy.
They are particularly indicated in the case of pregnancy, breast feeding, multiple therapies for comorbid diseases, poor tolerability of drugs, childhood and elderly.
Numerous prophylactic medications are available for this chronic disorder; however most of them have major shortcomings primarily due to variable efficacy and poor tolerability due to side effects.
Second, the patient had either poor tolerability (quetiapine), adverse allergic reaction (carbamazepine), or non-response (risperidone, divalproex sodium) to other treatment options.
