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According to the Toth et al. (2012) a poor soluble solute would own weak interaction with the solvent.
However, commercially available FDM printers are extremely limited with regards to the materials that can be processed to few types of thermoplastic polymers, which often may not be pharmaceutically approved materials nor ideal for optimizing dosage form performance of poor soluble compounds.
Only in five cases was poor soluble protein expression observed.
High thermodynamic stability, high molecular weight, increased hydrophobicity and areas of low sequence complexity are linked to poor soluble protein expression yields [ 16].
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Because of poor solubility, water-soluble prodrugs of CA-4 and CA-1 have been developed, which are currently in human clinical trials.
In order to generate powders with different dissolution characteristics, a part of powder was stored at 25 °C (well-soluble powder) and the remaining part was stored at 40 °C (poor-soluble powder) for 2 weeks.
However, surfactant adsorption may decrease at high temperature conditions for highly soluble surfactants, and, on the other hand, poor solubility may lead to high adsorption values.
All of the cis-polyimides were soluble at room temperature in aprotic polar solvents and phenolic solvents and some of them even soluble in chloroform and tetrahydrofuran, while the corresponding trans-polymers showed poor solubility as compared to cis-polymers.
The drug exhibits poor solubility and hence mesylate salt was used for its development, which is soluble in water at pH<5.5 22, 22.
So, MIC is a successful technique to enhance aqueous solubility and skin permeation of poor water soluble drug especially when loaded into transdermal films.
It is a poor water soluble drug with absolute bioavailability of 10%.
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