Moreover, the limited potency and poor oral solubility hinders its clinical development.
Shikonin exhibits powerful anticancer activities for various cancer cells, but its poor solubility and strong toxicity hinder its development as clinical anticancer agent.
However, the poor solubility of SWCNTs in water hinders their use in biomedical applications and nanomedicine.
Thin-film fabrication of polyurea is hindered by poor solubility in most organic solvents.
Unfortunately, there are several factors which influence the photocatalytic performance of Ag3PO4, such as irregular morphology, poor solubility, unstability, high cost, etc., which hindered its widespread applications [5].
However, clinical potential of GEN was hindered due to its poor solubility (~1.43 μg/ml) and low bioavailability.
However, their introduction into the clinical setting may be hindered largely by their poor solubility, rapid metabolism, or a combination of both, ultimately resulting in low therapeutic concentrations at the target site.
Development of an oral docetaxel formulation has been hindered mainly due to its poor solubility and oral bioavailability.
However, its poor solubility in many solvents and chemicals and weakened biocompatibility greatly hinder CNT applications in actual systems [8, 9, 10, 11, 12].
High melting points are usually desirable, but may contribute to poor solubility and are as troublesome as low melting points, which can hinder processing, drying, and stability.
Following the maximum value, the intensity of cGMP and guanosine were constant, due to poor solubility of guanine.
