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The poor side effect profile of progestagen-only injectables is extensively documented.
However, it has a low therapeutic index due to limited potency and a poor side effect profile [ 2, 3].
Some of these have been plagued by poor side effect profiles whereas others have been well tolerated, but ineffective.
Immunotherapy is the only causal treatment for allergies, but continues to have low acceptance due to inconvenient dosing and a poor side effect profile.
Bromocriptine dominates the literature, yet it has a poor side effect profile both in terms of short-term administration (as shown in several of the trials reviewed here that tried to push the dose to 30 mg/day and beyond) and in terms of longer-term risks of cardiorespiratory fibrosis.
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As tricyclic antidepressants (TCAs) lack efficacy for depression treatment in this age group and have a poor side-effect profile, 3 selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed pharmacological treatment for children and adolescents.
Indeed, if these physicians truly believe that diuretics cannot be used as first-line therapy for the treatment of mild to moderate hypertension due to their poorer side effects profile and their lower effectiveness in reducing patients' blood pressure compared to other drugs, why is it that diuretics can be seen as an acceptable second-line therapy?
Further, all these agents had a poorer side-effect profile compared to sorafenib.
In comparison with dronedarone, amiodarone may be more efficacious for maintenance of sinus rhythm, but it has a poorer side-effect profile, particularly with long-term use.
The current drugs to treat HAT are inadequate due to poor efficacy, side effects and the requirement for parenteral administration, which is not appropriate for a rural African setting. 1, 2 Herein we report a target-based approach to the discovery of novel inhibitors of trypanothione reductase (TryR) as a potential therapy for HAT.
The current drugs to treat HAT are inadequate, due to poor efficacy, side effects and the requirement for parenteral administration, which is not appropriate for a rural African setting. 2 Folate metabolism has been successfully used as a drug target in a number of diseases such as cancer, bacterial infections and malaria.
More suggestions(15)
worst side effect
poor antimotility effect
poor dehydration effect
poor affusion effect
poor lubricating effect
poor rank effect
poor compression effect
poor contrast effect
poor side view
poor intervention effect
poor efficacy effect
poor balance effect
poor painkilling effect
poor chemotactic effect
poor membrane effect
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