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But majority of Plm II inhibitors suffered from poor selectivity over cathepsin D as well as other subtypes of plasmepsins.
Several 1,3-dipropyl derivatives endowed with nanomolar binding affinity at hA2B receptors, but poor selectivity over hA2A, hA1 and hA3 AR subtypes were identified.
However, even the most potent of these peptides has poor selectivity over GRK3 (2.6 μM) or GRK5 (1.6 μM).
To confirm the data obtained from the screening samples, a further array of compounds was synthesised (table S2, Supporting Information); these, however, displayed only moderate potency and poor selectivity over HsCDK2.
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Furthermore, they exhibited poor selectivity for PfCDPK1 over a panel of human kinases, and their anti-parasite effect may be driven by significant off-target activity.
One possible strategy to circumvent the poor selectivity of the quinols for T. brucei over MRC5 cells is to selectively target them to the trypanosome.
On the other hand, the presence of PVA stabilizer on the surface of the SI catalyst resulted in the preferential oxidation of alcohol over aldehyde group in glucose, leading to poor selectivity of the cascade process.
On Cu13 and Cu38 clusters, C2H2 easily undergoes over-hydrogenation to form ethane via CHCH2 and CHCH3 intermediates, namely, both clusters exhibit a poor selectivity towards C2H4 formation.
TOPO shows high extraction coefficient but poor selectivity.
"Most drugs," he says, "especially psychiatric drugs, have very poor selectivity.
However, high cost, poor selectivity, and instability of Au make it unsuitable for practical applications [21].
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