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Though Kahaani received critical acclaim, it was a slow starter at the box office, opening to a poor response on the first day, but gradually picking afterwards.
As well as for chemotherapy, a high interstitial fluid pressure (IFP) is also a prognostic marker for poor response on irradiation [ 59].
Patients with a blastoid variant of MCL are more likely to have a rapidly progressive course, and a poor response on chemotherapy.
Given the high prevalence of suspected factors (young age (60%), viral infection (60 80%), ETS (20 30%)), the potential impact of poor response on the rate of failure of ED management is sizeable.
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The high proportion of AA patients enrolled in the Virahep-C study allowed us to assess the effect of HCV's genetic variation on the unusually poor response of AA patients to therapy.
This is consistent with several recent studies showing a strong correlation between centrosomal disturbances and/or spindle multipolarity, on the one hand, and poor response to treatment, on the other hand, for several tumor types, including urothelial cancer [9], [11], ovarian cancer [47], head- and neck-cancer [48], breast cancer [49], Wilms tumor [10], and multiple myeloma [50].
We found that even moderate consumption of alcohol (>7 drinks per week) predicted a poorer response on all the assessed scales.
Interestingly, the majority of patients analyzed revealed strong YY1 expression and showed poor response to chemotherapy based on Huvos grading system.
In addition, recent efforts such as the HapMap project – a database of genetic variations associated with human diseases and response to pharmaceuticals – may shed light on poor response to disease-modifying drugs in some patients with rheumatoid arthritis.
Poor response to IFNβ was based on quantitative MRI analysis, comparing the MRI at the 6-month visit with baseline.
We demonstrated this effect by tending to avoid material from publishers from whom we would anticipate poor response to our requests, based on our early experience.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com