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This poor remodelling outcome observed for cellular content in vivo may also be potentially caused by reduced proliferative capacity in vitro.
Exaggerated trophoblast apoptosis has been associated with the poor remodelling of maternal spiral arteries seen in pregnancy complications such as PE and FGR, yet the underlying mechanisms are poorly understood (Smith et al., 1997a; Leung et al., 2001).
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Patlak-like slope differences of 0.1 min−1 or greater between examinations and SUVmax differences of ~5 usually indicated good remodeling progress, while negative Patlak-like slope differences of −0.06 min−1 usually indicated poor remodeling progress in this cohort.
Preeclampsia is a prevalent and enigmatic disease, in part characterized by poor remodeling of the spiral arteries.
However, full repair or function of the long bone could be limited due to the poor remodeling of the HA/TCP material.
In contrast, the majority of 6 months specimens revealed poor remodeling and fissured integration with host cartilage while other samples could maintain good cartilage appearance.
Defects such as poor EVT migration/invasiveness, poor remodeling of the spiral arteries, and dysregulation of syncytialization, have been observed in severe pre-eclampsia (PE), which in turn, may result in intrauterine growth restriction (IUGR).
Autophagy impaired by sEng may partially be related to poor placentation in PE due to suppressed EVT invasion and poor vascular remodeling [ 79].
The mechanisms responsible for the poor trophoblast invasion and inadequate remodelling have yet to be determined although a reduced capacity to invade and/or increased sensitivity to apoptotic stimuli may play a significant role.
The altered expression of secreted factors of dNK cells may contribute to pregnancy disorders associated with poor spiral artery remodelling.
PE develops in two stages; the first (preclinical) stage comprises poor spiral artery remodelling (8 18 weeks), leading to dysfunctional perfusion and placental oxidative stress.
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