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Health states are defined using ACR20/50/70 response criteria and the next treatment option in the particular sequence is selected after poor remission or adverse events.
Furthermore, there have been recent reports of a shift in the balance of immune and neurotrophic mediators over the course of established BD, suggesting the development of a more severe dysregulation in the immune system and reduction in neurotrophic factors in patients with recurrent episodes of illness, poor remission, and a high burden of illness (Berk et al. 2011; Kauer-Sant'Anna et al. 2009).
They are retrospective, have poor remission rates or small numbers of patients.
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The assessment of comorbid personality pathology or traits in these disorders is relevant, because it can lead to the exacerbation of them or to poorer remission rates.
These authors reported that elevated depression symptoms predicted a lesser decrease in CRP across the month following the cardiac event, which the authors describe as reflecting a poorer remission in the underlying inflammatory process.
This study shows that older patients (≥ 60) present with more co-morbidities than younger patients, have a poorer remission status and more complications of chemotherapy, and are more likely to stop chemotherapy before completing prescribed cycles due to severity of disease and economic factors.
Comorbidity with anxiety disorders was an independent factor related to poor treatment remission of abdominal pain.
Delayed diagnosis, and sub-optimal treatment contribute to the substantial burden of illness and poor quality of remission (Hirschfeld et al. 2003; Schaffer et al. 2006).
One type of bipolar disorder appears related to psychotic illness with early adolescent onset of psychotic manic or mixed episodes, male preponderance, neurodevelopmental comorbidity, poor quality of remission, family history of psychotic or chronic mood disorders and failure to fully respond to lithium prophylaxis (Grof et al. 2009; Alda 2004).
Spatial working memory scores were significantly poorer for the remission group compared to those for the HCs with medium to large effect (Cohen's d with Hedges' correction = 0.72).
18 As with the overall AML population, there was poorer survival and remission duration in the older versus younger patients regardless of NPM1/FLT3 mutation status.
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