Because the antibody repertoire of these cells is restricted by previous antigenic experience, they make poor quality responses to new immunologic insults.
11 If women disclose DV to a clinician, whether in a primary care or specialist setting, there is evidence of an inappropriate poor-quality response.
Another problem of particular significance for Raman spectroscopic analysis arises from the recovery of broken ceramics from archaeological excavations, where the assimilation of fluorescent materials from the burial environment has occurred which often has resulted in high levels of background fluorescent emission and resultant poor quality Raman spectral response.
Radiation dose estimates were not available for 25 cases (15%): 2 were ineligible, 17 could not be traced, 4 refused to complete the dosimetry questionnaire, and 2 had poor quality of interview response.
A partial response (PR) is defined as a poorer quality haematological response, with persistence of splenomegaly, cytopenias or presence of circulating hairy cells on blood smear analysis.
Drug and alcohol related issues were the most frequently stated followed by abandoned property, litter, homeless issues, high crime rate, lack of affordable shopping, poor police response, poor quality grocery stores, and lack of parks/recreational facilities.
Nonetheless, they indicate that, in addition to the impact of B cell compartment (e.g. follicular to MZ/B1 skewing), 'defective' T cell help may contribute to the poor quality of the humoral response of aged individuals.
Progressive weight loss is a common feature of cancer and is responsible not only for a poor quality of life and poor response to chemotherapy, but also short survival time irrespective of tumor mass or the presence of metastases, and it also interferes with cancer therapy [ 2].
Thus, the poor quality of the primary humoral response of aged animals probably reflects the mixed response of specific naïve B cells and polyreactive antigen-experienced B cells, rather than some B cell functional defect.
UNCST staff attributed the low response and poor quality of the proposals to a number of reasons.
Neuropathic pain is consistently linked to high levels of pain, disability, poor quality of life and poor response to treatment [ 14, 16, 17] and is therefore a difficult condition to treat successfully [ 14, 16].
