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"There [was also] a clear relationship between increased OCS concentration and poor pulmonary function," says Cooper.
To assess the feasibility and outcomes of 125I Vicryl mesh brachytherapy after sublobar resection in stage I nonsmall cell lung cancer (NSCLC) patients with poor pulmonary function.
Surgical resection is regarded as a standard treatment for early NSCLC while radiotherapy has been offered to patients who are not suitable for surgery due to medically inoperable factors such as poor pulmonary function or severe cardiovascular dysfunction [1].
Data presented here provides insights into the CF airway microbiota, including initial diversification events in younger patients and establishment of specialized communities of pathogens associated with poor pulmonary function in older patient populations.
Evidence for initial diversification in younger patients, decreases in diversity in older patients and the presence of specialized communities of phylogenetically related species (Fig. 3) associated with poor pulmonary function in these older patient suggest that CF airway microbiota may also follow the rules of community assembly previously reported at other host niches.
Two patients had poor pulmonary function and advanced lung disease at presentation for surgery.
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In effect, subjects with poorer pulmonary function tended to have greater breath carbonyl sulfide concentrations [14].
From a cohort of clinically stable patients, we demonstrate that older CF patients who exhibit poorer pulmonary function possess more uneven, phylogenetically-clustered airway communities, compared to younger patients.
It is postulated that poorer pulmonary function may be associated with increased levels of inflammatory mediators.
This strain also appeared to show increased virulence as it was associated with increased hospitalisation and poorer pulmonary function amongst infected patients [ 10, 11].
Independent risk factors for death included diabetes (hazard ratio 1.31 [95% CI 1.03 1.67], female sex (1.71 [1.36–2.14]) plus poorer pulmonary function, lower BMI, Burkholderia cepacia infection, absence of Staphylococcus aureus infection, allergic bronchopulmonary aspergillosis, liver disease, prior organ transplantation, and corticosteroid use.
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