The basis of this switch is the modification of a residue with poor PPII propensity (Ser or Thr) to a residue with substantially greater PPII propensity (phosphoserine or phosphothreonine).
A second helix at the N-terminus of SERT (hII) is predicted to include residues G18 E23 [according to PSIPRED] or to extend to N24 [in the models], though this region has a poor helical propensity according to the meta-structure prediction.
Collectively, these data suggest that the very poor PPII propensity of aromatic residues in proline-rich sequences, in contrast to non-proline-rich sequences, is due to the special interactions of the proline residues with the aromatic rings inducing multiple cis amide bonds and non-PPII structure.
An unintended consequence of introducing mutations in the Fc (particularly the CH2 domain) can be a reduction in biophysical stability which can correlate with increased aggregation propensity, poor manufacturability, and lower solubility.
Be conscious of signs of over training which include but are not limited to; constant fatigue, poor performance, irritability, propensity for injury and inability to sleep.
On the other hand, one of the significant drawbacks to the use of KLH as a TAAs carrier in antitumour vaccines is their poor solubility and propensity to aggregate and precipitate (Gathuru et al, 2005).
However, a subset of patients aged 80 or older with at least one non-skeletal risk factor for hip fracture (poor gait or propensity to fall) was also examined and no significant difference was found in fracture rate between risedronate and placebo (McClung et al 2001).
Credit checks are still used by many employers as an input to the hiring process despite a lack of evidence linking poor credit with a propensity to perform poorly in the workplace (several states have actually passed laws limiting the use of credit checks in employment evaluations).
Pancreatic cancer is a deadly disease with a poor prognosis and a propensity to rapidly metastasise to tissues and lymph nodes while exhibiting resistance to cancer-directed immune mechanisms.
