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This result was confirmed in PBMC and liver biopsies obtained from the same patients, even if not statistically significant due to the poor number of samples.
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The WQI calculated showed that the number of samples rated as poor, very poor and unfit constitute about 50% of the total samples thereby pointing out to the fact that the groundwater of these needs some degree of treatment before consumption, and it also needs to be protected from the perils of contamination.
GSE39004 has a poorer AUC, consistently with the limited number of samples available for the k-fold validation.
Although important, gene signatures have many issues as descriptors - for instance, loss of specificity in validation studies with an increased number of samples [ 10], generally poor cross-platform compatibility (Amsterdam and Rotterdam signatures virtually do not overlap in gene content), lack of mechanistic (functional) correlation with phenotype, etc.
The latter might lead to a poor fit of the tail due to an insufficient number of samples.
An alternative hypothesis for poor performance of replication groups scoring is the low number of samples in the data sets.
This, along with poor DNA yield from some nasal swabs, ultimately limited the number of samples available for analysis.
If the number of features is much greater than the number of samples, the method is likely to give poor performance.
Array CGH was used to validate the clonal predictions based on methylation but only a small number of samples were assessable by aCGH due to poor DNA quality.
The melanoma-class has a lower number of samples, it is the minority class and it also tends to have poor classification results.
There is no specific criterion about the number of samples (events) required to accurately train the system, even overtraining can also result in poor classification accuracy.
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CEO of Professional Science Editing for Scientists @ prosciediting.com