Sentence examples for poor metabolisers from inspiring English sources

Approximately 7 10%% of Caucasians and 1 3 % of Asians are poor metabolisers of drugs metabolised by CYP2D6 [ 93, 94].

Because poor metabolisers are unable to metabolise CYP2D6 substrates, a drug administered at normal dose may lead to high or toxic levels of the drug [ 11, 12].

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification.

CYP2D6*3, *4 and *5 together predict about 90% of poor metabolisers [53].

Seven percent of white Caucasians and 1 2% of Blacks and Orientals [39, 52] do not express this enzyme and are "poor metabolisers".

Some patients possess polymorphisms in specific places on the 2C19 gene that make poor metabolisers of those drugs; physicians can test for these polymorphisms and find out whether the drugs will be fully effective for that patient.

Here we found that an important fraction of the subjects is carrying EFV/NVP poor metaboliser alleles.

Moreover, concerning the CYP2B6 expected phenotypes, 28.57% of the population showed a poor metaboliser phenotype, while 27.38% and 44.05% showed an extensive (wild-type) and an intermediate metaboliser phenotype, respectively.

Women with a CYP2D6 poor metaboliser phenotype developed fewer hot flushes than women with an extensive metaboliser phenotype.

CYP2D6 genotypes were then classified into three phenotypic categories, ranked from low to high level of enzymatic function: poor metaboliser, intermediate metaboliser and extensive metaboliser.

Unadjusted matched logistic regression revealed no significant difference between cases and controls for extensive vs intermediate metaboliser phenotype (OR=0.81 (0.30–2.23), P=0.7) or extensive vs poor metaboliser phenotype (OR=1.02 (0.31–3.32), P=0.9).