One interpretation of high β diversity is that it reflects poor connectivity between meta-communities, assuming that localised disturbance events have not led to local extinction.
Aryl boronic acids with electron-rich, electron-poor, and ortho, meta, and para substituents all performed well (products 3 a– 3 k).
Poor reporting in meta-analyses and RCTs is crucial because both designs are considered to be the gold standard in evidence-based practice.
Although not all trials were conclusive and some were of poor methodologic quality, meta-analyses demonstrate that intravenous alpha-lipoic acid treatment is associated with significant short-term pain relief and improvements in nerve conduction [ 92, 95].
To lower this risk, adjuvant chemotherapy has been advocated for patients with pT4 and/or lymph node positive (N+) disease because of their generally poor prognosis (Advanced Bladder Cancer ABCC) Meta-analysis Collaboration, 2005; von der Maase et al, 2005).
Compounds with ortho substitution showed poor activity and with meta and para substitution showed good activity.
Results indicate that human operators can compensate for a poor performing aid when meta-information is available.
As mentioned in Section 2.1, the poor classification accuracy of meta-cluster I is understandable, since that cluster contained the largest number of tags and was also considered to contain the weakest links between the tags (see Figure 1).
We excluded any studies that had poor quality from the meta-analysis.
Although some studies have shown KRAS mutations in NSCLC are associated with poor prognosis, including a meta-analysis of 28 studies (Mascaux et al, 2005; Johnson et al, 2013), conflicting results from other studies (recently reviewed in Martin et al, 2013) mean the prognostic impact of KRAS mutations in NSCLC remains unclear.
