Using PET alone, there is poor disease localisation, and specificity can sometimes be low [7], as other pathological or physiological processes may lead to increased bowel fluorodeoxyglucose (FDG) uptake.
F-FDG PET alone suffers from poor anatomical localisation of head and neck cancers and their metastases.
Determining the precise location of F-FDG-avid lesions by PET alone can be challenging in these patients, as the test suffers from poor anatomical localisation that might compromise sensitivity (Ak et al, 2000).
The present continuative long-term follow-up strengthens the assumed link between increased nuclear LASP-1-localisation and poor survival of patients with breast cancer suggesting an effect of nuclear LASP-1 on cell proliferation, especially because the absolute amount of cytosolic LASP-1-expression does not correlate with patients' OS.
The present continuative long-term follow-up provides evidence for the relation of increased nuclear LASP-1-localisation and poor survival of patients leading to the question whether nuclear LASP-1-positivity defines a subgroup of patients with unfavourable prognosis that is not responding to conventional treatment approaches.
MRI is less affected by dental artefacts as compared to CT. Involuntary patient motion between the CT and the PET data acquisition of a PET/CT study can lead to poor data fusion, making correct localisation of focal uptake impossible especially in smaller lesions and in the supraclavicular area (see "Increased FDG thyroid gland uptake").
Typical symptoms are poor recognition, discrimination, separation, grouping, localisation, ordering of non-speech sounds and difficulties with acoustic tasks when competing acoustic signals are present [ 75, 76].
Its localisation (if any) is poor in LNs and thymus.
In addition, HER4 nuclear localisation is associated with poor survival and CYT2 has been found to enter the nucleus more readily than CYT1 (Junttila et al, 2005; Sundvall et al, 2007; Zeng et al, 2007).
