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This estimation problem is very challenging due to the non-linear character of the dynamics, the large number of parameters and the frequently poor information content of the experimental data (poor practical identifiability).
The lack of detection of this QTL in the previous QTLExpress analysis [ 4] could be due to the poor information content of several sire families at markers surrounding the QTL region, which is best taken into account by the QTLMap software.
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Those with low health literacy and numeracy may be especially susceptible to misleading information and framing effects [ 32], whether these are intentional, as in malicious behaviour in an online community, or whether they simply reflect a poor fit between information content, its presentation, and the learner.
The remaining 19 drug entries were not considered for cost analysis as information content was too poor to estimate a price.
We note that isothermal operation is least desirable, as it is very slow and offers poorer discrimination, owing to the limited information content when operating at a single temperature.
Another reason for missed InterPro entries seems to be that they are either short (with poor separation of signal and noise due to insufficient information content in the profile) or lineage-specific.
If even the best hit has a poor E-value, it is most likely that the information content in the spectrum is hard to retrieve due to high noise level.
Milne and colleagues now show that a protein named RUNX1 cooperates with two different MLL mutations to alter the epigenetic information content of the cell, directly contributing to the poor prognosis of MLL-associated leukemias.
Worst of all, because low information content makes apparent optima more variable, the poorer the optimization method, the more frequently one will feel compelled to re-optimize the patient (unless we ask about information content).
Another explanation is that the information content of the S. cerevisiae dataset might be relatively poor so that it benefits from the incorporation of any of the two other datasets.
We propose a novel procedure that is less sensitive with respect to poor a-priori knowledge; it relies on an optimization problem to maximize the information content of the measurement data for the purpose of model identification.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com