Structure elucidation of the VUF11211 metabolites was complicated due to the poor fragmentation pattern of the parent compound.
In contrast, RiPPquest aims at discovering peptides with poor fragmentation and extensive number of modifications by characterization of the core peptides from genome sequences.
The presence of proline is detrimental for mass spectrometry peptide fragmentation using collision induced dissociation (CID) as the "proline effect" leads to a poor fragmentation pattern [ 28].
A number of DNA fragmentation methods, such as hydrodynamic sharing, sonication or DNase I fragmentation, have various drawbacks, including DNA damage, poor fragmentation control, irreproducibility and non-overlapping DNA segment representation.
We have new software that can help poor countries understand the fragmentation of their trade but UN Comtrade (the world's trade database) is still hoarding bulk data.
Despite this apparent victory of global health over narrow state interests, a number of countries and commentators have argued that the IHRs actually undervalue "equity between developed and developing nations" (86, p. 482) and risk fragmentation of poor countries' health systems and "national health priorities set up by developing countries" (87, p. 13).
Ecologists stress more work needs to be done to pinpoint the reasons behind the decline, but said likely candidates are habitat loss, poor management of hedgerows and fragmentation of habitat, due to new roads, housing and other developments.
However, the contracting of a number of different insurance schemes to purchase services for the poor in India and Georgia did result in fragmentation of pools.
In addition, the healthcare system seemed to inadequately promote preventive care, mainly due to poor reimbursement for preventive care and fragmentation of care.
This highlights the fragmentation of healthcare services, with poor referral links across the types and levels of healthcare services in India.
