Prophylaxis of primary pediatric headaches has some limitations: poor efficacy, adverse effects, contraindications for comorbidity, off-label use of drugs in pediatric age, limited knowledge and few controlled studies.
The current drugs to treat HAT are inadequate due to poor efficacy, side effects and the requirement for parenteral administration, which is not appropriate for a rural African setting. 1, 2 Herein we report a target-based approach to the discovery of novel inhibitors of trypanothione reductase (TryR) as a potential therapy for HAT.
The current drugs to treat HAT are inadequate, due to poor efficacy, side effects and the requirement for parenteral administration, which is not appropriate for a rural African setting. 2 Folate metabolism has been successfully used as a drug target in a number of diseases such as cancer, bacterial infections and malaria.
Although most of these treatment methods are effective, most patients still have a pleasant experience either due to poor efficacy or side effects or both.
However, these treatments show poor efficacy and outcome [25].
As drugs for treating this type of injury have shown poor efficacy and adverse side effects in clinical trials, a novel therapeutic strategy has been long awaited.
7 There is thus a climate of caution about antidepressant use in general and particularly in adolescents, due to evidence of poor efficacy and high side effects.
Treatment with antidepressant medication is not recommended for initial treatment in young people due to concerns over high side effects, poor efficacy and addictive potential.
The main reason for not being willing to talk with patients (75.57%) were that the medical staff worry about poor efficacy and the side effects of testing drugs in clinical trials.
The test of several compounds targeting other protein kinases, like cdk1/2/9, p38, Erk1/2, JNK, casein kinase, and DYRKIA brought disappointing outcomes, and trials were discontinued due to the poor efficacy or severe adverse effects.
