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Problems are present due to the poor diffusion of the hydrophilic product in the tumours.
This is due to poor diffusion of the very large and slow polymer chains across the inter-filament interface.
Charge transfer reactions of electroactive reagents in pure Nafion film are generally slow due to Nafion's compact nature and the poor diffusion of ionic species within the film.
However, the absence of inhibition by the antibodies might be related to the poor diffusion of antibodies into the cartilage.
However, a common drawback of fungal solid-state cultures is the poor diffusion of oxygen into the fungi that limits its growth and biological productivity.
Treatment of VAP caused by MDROs has been limited by the poor diffusion of certain intravenous antibiotics (for example, aminoglycosides) into the alveolar compartment of the lungs.
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A poor diffusion would involve retention of enzyme molecules in the pore mouths preventing new ones to access the channel and leading to a low enzyme loading of the catalyst.
This might be a result of poor diffusion strategies or it might indicate that the interventions do not meet the needs and wishes of the target group.
The reasons of this poor diffusion include high costs compared to the added value achieved, technology constraints (regarding precision, reliability, and performances), and, generally speaking, the lack of killer applications.
The use of an intact immunoglobulin as the CAIX-targeting moiety for imaging purposes in this setting was originally thought to be limited because of the relatively poor diffusion from the vasculature into and through the tumor [32].
The diffusion of antibiotics in the endocarditis vegetation bacterial masses has not been previously reported, although poor diffusion is a potential risk factor for antibiotic therapy failure.
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