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Problems are present due to the poor diffusion of the hydrophilic product in the tumours.
Antibiotics with poor diffusion through biological membranes are appropriate candidates for nebulization, as intravenous infusion results in low lung concentrations.
This is due to poor diffusion of the very large and slow polymer chains across the inter-filament interface.
Charge transfer reactions of electroactive reagents in pure Nafion film are generally slow due to Nafion's compact nature and the poor diffusion of ionic species within the film.
The reasons of this poor diffusion include high costs compared to the added value achieved, technology constraints (regarding precision, reliability, and performances), and, generally speaking, the lack of killer applications.
To overcome some limitations of LDH-type materials when prepared by conventional coprecipitation arising from poor diffusion and accessibility to active sites, however, prerequisites in many applications, these materials were designed as macroporous open structure.
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The considerable drop in Jsc of the co-sprayed device (run 10m) is perhaps due to the low thickness of the active layer and consequently the short diffusion length and poor photon harvesting efficiency [1, 19, 21, 22, 44, 45].
These include the susceptibility to digestive enzyme degradation, instability in the acidic pH environment, poor mucus diffusion and inadequate permeation through the gastrointestinal epithelium.
The formation of these aggregates also has a direct impact on the oxygen concentration in their surroundings due to cellular respiration and poor oxygen diffusion through clusters.
Although the use of TiO2 photocatalyst on cementitious materials for air purification has been developing rapidly in the last decades, the photocatalytic effect of TiO2 is significantly diminished due to the low specific surface areas, poor gas diffusion and light transmission performance of cementitious substrates.
This is a matter of concern, because poor antibiotic diffusion in vegetation bacterial masses may be a risk factor for treatment failure.
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CEO of Professional Science Editing for Scientists @ prosciediting.com