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Reconstruction of critical size bone defects remains a major clinical challenge because of poor bone regeneration, which is usually due to poor angiogenesis during repair.
Three of the complications involved soft tissue contractures, which were successfully treated with one additional surgical procedure, whereas the fourth complication involved poor bone regeneration and required bone grafting and additional immobilization.
However, the use of poly(lactide) implants in bone has been disputed because of poor bone regeneration at the site of implantation.
It also had different radiographic feature with poor bone regeneration in the distraction gap, and the callus was scarcely fusiform or cylindrical but lateral or central shaped.
However, it was characterized by poor bone regeneration in the distraction gap with different types of callus from normal, greater healing index and prolonged fixator wearing, which should be pay more attention to.
In the 8 patients with proximal tibial dysplasia, 5 cases had lateral callus, 3 had central callus, and poor bone regeneration was observed in all of them with an average HI of 67d/cmm.
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Moreover, they have poor blood supply and bone regeneration.
However, the poor mechanical performance and poor bioactivity limit its application in bone regeneration.
The use of poly (butylene adipate-co-terephthalate) (PBAT) in tissue engineering, more specifically in bone regeneration, has been underexplored to date due to its poor mechanical resistance.
However, the relatively poor mechanical properties of the HAP/Col composite porous scaffolds limit their application in bone regeneration.
Despite good results from many studies which used chitin as a membrane for guided bone regeneration [15 18], problems with the exclusive use of chitin involve its poor mechanical properties.
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