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Analysis of the MD trajectories for the two complexes reveals interesting features which may explain the stability of the complex obtained for the first molecule versus the poor binding of the other ligand.
It presents that the contact angle of the FTO surface to the P3HT ICBA blend solution is 46.5° ± 2.5°, indicating a poor binding of the blend droplet to the FTO surface.
It may be caused by poor binding of non-neutralizing antibodies and delivery into the wrong compartment of white blood cells that have ingested the virus for destruction.
The defect was not due to poor binding of the IHD-J strain to S2 cells as determined by flow cytometry using recombinant viruses with GFP fused to a core protein (data not shown).
According to this model, reduced parahippocampal wiring induces an information processing 'syndrome' characterized by poor binding of event components, with a predominant representation of object information at the expense of context information.
Mutations in the conserved HMG box domain and its up/down stream sequences have been correlated with sex reversal or poor binding of the SRY protein to the target DNA [15].
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This can be explained by poorer binding of the inhibitor to the active site of the mutated protein.
In two variants (H3mm10 and H3mm17), amino acid substitutions in the histone chaperone-binding domain may explain the lack of chromatin incorporation because of poor binding to chaperones [ 18– 20].
For instance, S. Livingstone and S. Worthington were not easily detected by some of the ELISA methods used, probably because of poor binding to the antibodies.
A difficulty has been the relatively poor binding power of the targeted microbubbles, especially in the non-immunogenic form suitable for human use.
We therefore suspect that missing genotypes in this data set arise primarily from the allelic dropout caused by low DNA concentration or quality in some samples and that locus-specific factors such as poor binding affinity of primers and polymerase have a smaller effect.
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