In solvent which is poor for the backbone, stiff macromolecules form filament clusters from few intertwined helical chains.
As a result there is a poor understanding of backbone traffic variability, and its impact on network operations (e.g. on capacity planning or traffic engineering).
"But nor should we cater to the wealthy at the expense of our middle-income workers and working poor, who are the backbone of every American community".
By contrast, CHS-PPhe, owning the same Phe functional groups but comb-like architecture (polyPhe polymer branches grafted on chitosan backbone), shows poor performance.
The trees inferred from the full datasets, as well as the species tree, had poor support for the backbone of the phylogeny, with most bootstrap values being less than or close to 50%% (Figs. 2, 3, 4 and 6, Additional file 3: Table S3, Additional file 4: Figure S1, and Additional file 5: Figure S2).
TMAO solution is clearly a much poorer solvent for the backbone than water, and the large unfavorable free energy of the peptide backbone is reduced through contraction/secondary structure accretion of the DSE and particularly from burial of the backbone through folding.
The position of the electron-rich phosphate is clear for both ligands, but the density of the carbon backbone was relatively poor, revealing the general path of the ligand but not specific details and leading to high B-factors.
Clearly, sarcosine and TMAO are poor solvents for the peptide backbone.
The improved model selection can be attributed to the improved side-chain quality, which enables the MQAP to rescue good backbone models with poor side-chain packing.
