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On the other hand, gastrointestinal motility test indicated its poor antimotility effect.
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However, because of its antimotility effect, its safety against contracting resistant intestinal bacteria has been questioned.
Results from studies in our laboratory have recently demonstrated that overexpression of CCN5 protein has an antiproliferative and antimotility effect on VSMC [ 4].
The remarkable antimotility effect of Lantana camara methanolic extract against neostigmine as promotility agent points towards an anticholinergic effect due to Lantana camara constituents and attests to its possible utility in secretory and functional diarrheas and other gastrointestinal disorders.
Some researchers have posed the question as to whether the antimotility effect of loperamide, involving prolonged passage through the gastrointestinal tract, would, in fact, increase the risk for colonization (data not shown).
Theoretically, an additional increase in the risk seen in the combination group could be brought about by loperamide: because of its antimotility effect, contact time of the AMD to the gut lumen is increased, and the selection pressure posed by the AMD may be prolonged, thus intensifying its unfavorable effects.
The remarkable antimotility effect of Lantana camara methanolic extract against neostigmine as promotility agent points towards an anticholinergic effects due to Lantana camara constituents and attest to its wide range of utility in secretory and functional diarrheas and other gastrointestinal disorders in the folklore.
Loperamide, a drug with both antisecretory and antimotility effects (11 ), is widely used by travelers (12 ).
The purpose of the present study was to evaluate the antimotility effects of Lantana camara leaf constituents in mice intestine.
In vitro studies with human TCC cell lines show that BCG exerts cytolytic, antiproliferative and antimotility effects.
Cytotoxic drugs usually show poor therapeutic effect.
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