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We note that high FI scores could be the result of a poor alignment with the outgroup sequence.
After excluding patients with motion artefacts, poor alignment with histology, and benign and nonbreast-originating disease, nine patients were evaluable.
Furthermore, cytoarchitectonic zones, including BAs 44 and 45, have been shown to have poor alignment with macroanatomy in the frontal lobes (e.g., [ 14, 27 29]).
32 Collectively, these results reflect widespread lack of knowledge of gout and poor alignment with current recommendations of best practice within the UK.
The PfSSM (Plasmodium falciparum Specific Substitution Matrices) were developed basically for P. falciparum and particularly for those proteins which do not find their orthologs in other eukaryotes or show very poor alignment with their orthologs.
In case of Plasmodium falciparum, PF11_0220 (Molecular Function GO 0004672, protein kinase activity, evidence code IDA, source: http://www.plasmodb.org) is a known protein kinase which shows poor alignment with known yeast protein kinase with BLOSUM series of matrices.
Similar(52)
All hemiascomycetous yeast proteins involved in glucan synthesis or its regulation are 3- to 10-fold longer in sequences, and show very poor alignments with SAKL0H22528p (not shown).
Two reasons for the lack of success of programs or interventions are poor alignment of interventions with the causes of the problem targeted by the intervention, leading to poor efficacy (theory failure), and failure to implement interventions as designed (program failure).
Alignments for these 340 sequences were extracted from the European Ribosomal RNA database [66] and then manually curated to remove columns with more than 90% gaps or with poor alignment quality.
With turbulent flow the endothelial cell turnover is high with poor alignment, inflammatory genes activation, and increase in oxidative stress.
The main source of variability could be the poor alignment of the transducer with the direction of the blood flow [ 10, 26, 27].
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