Sentence examples for poor affinity for from inspiring English sources

Synthetic fibres made from the homopolymer of acrylonitrile, for example, have excellent dimensional stability and resistance to weathering, chemicals, and microorganisms but poor affinity for dyes.

Cerebral tryptophan hydroxylase appears to have a poor affinity for oxygen and to be affected by slight hypoxia.

SL1m exhibits relatively poor affinity for the HIV-1 nucleocapsid protein, suggesting that the bulge plays other roles in genome packaging.

In contrast, substitution at the ortho or disubstituted at meta and para positions was disfavoured, as both the 2″-nitro compound (7d) and 3″, 4″-dichloro substituted analogue (7b) displayed equally poor affinity for the σ1 receptor.

It was found that salicylaldoximes were able to quickly cleave the P S bond of organophosphate and avoid the reinhibition phenomenon in the reactivation process, but they lacked reactivating ability due to poor affinity for AChE.

Within this framework, it has been shown ex vivo that adenosine and CGS21680, a stable A2A receptor agonist (with about 10 100-fold selectivity for A2A receptors over A10 100-foldceptorselectivityafornity for A2A receptors [17]), dilate middle meningeal and cerebral arteries respectively, a respover blocked by A1andeceptor A3tagonists [13, 18].

The assessments confirmed the nature of the agonistic ligands but showed that 4-phenyl-2-propionamidotetralin, a described antagonist, is a biased partial agonist at MT2 with poorer affinity for MT1.

However, at 10 µM all the EGCG analogs showed similar levels of inhibition of RIG-I signaling but did not affect IPS-1 constitutive activity, suggesting that the less effective inhibitors either had poorer affinity for RIG-I or less optimal pharmacokinetic properties (Figure 5A).

The RE also exhibited a 10-50-fold 10-50-fold 10-50-foldhe conjugates synthesized than for oestradiol-17 beta and, at the concentrations of conjugate routinely used in histochemical assays, it seems likely that considerable nonspoorerc binding taffinityce.

Unlike the methylated analogues of NHA considered above, MHA has the poorest affinity for gsNOSoxy and forms a low-spin complex with the oxidized enzyme whose rhombic EPR signal, g = [2.43, 2.29, 1.914], is similar to that of N-alkyl and N-aryl -N′ hydroxyguanidines complexed with mammalian NOSs, in which the guanidine N-OH group is coordinated to ferric heme.

In addition, based on the poor affinity of CGS21680 for the A2B receptors [17] and similar responses to adenosine, our data did not show any strong involvement of the A2B receptors.