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The result from lipase PS, on the other hand, showed poor activities with respect to both transformation and stereoselectivity, providing only 30%% conversion without any enantiomeric preference of product 5 b (entry 15, Table 2).
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Four compounds were ineffective with MIC >256 μg/ml (highest concentration tested), six exhibited poor activity with MIC > 100 μg/ml, four showed moderate activity with MIC > 50 μg/ml and two had notable anti-TB activity with MIC values 32 μg/ml.
Cell-surface-displayed AldO, however, showed an unanticipated poor activity with xylitol.
Compounds with ortho substitution showed poor activity and with meta and para substitution showed good activity.
Most compounds exhibited poor activities on APN compared with MMP-2.
Crude extracts and water fractions had moderate to poor antimicrobial activities with MICs ranging from 312 to 2500 μg/ml.
While monotherapy was well tolerated, it showed poor activity: 6% with partial response, 4% achieved stable disease and 10% showed clinical benefit.
The bpy, phen, dppz, and CrCl3 · 6H2O (Cr3+ as free ion) show poor activity in comparison with that of the metal complexes against the two bacterial strains.
In developing an alternative CoA-dependent fermentative butanol pathway, which includes an engineered ADO variant (ADOA134F), the study addresses known limitations, including the low bio-availability of butyraldehyde precursors and poor activity of ADO with butyraldehyde.
These are distinct from previously reported pathways that were based on fatty acid synthesis, where propane production is limited by the availability of butyraldehyde precursors and the poor activity of ADO with butyraldehyde.
Currently used β-lactam/β-lactamase inhibitor compounds are highly active against class A and various ESBLs, but with poor activity against class C and class D enzymes.
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