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The medicine was made using pools of plasma from 10,000 or more donors, and since there was still no screening test for the AIDS virus, it carried a high risk of passing along the disease; even a tiny number of H.I.V.-positive donors could contaminate an entire pool.
Separate pools of plasma from cases and controls were subjected to immunodepletion to remove abundant plasma proteins, followed by differential isotopic labeling to distinguish cancer cases from controls.
Pools of plasma showing SIVmac239-specific NAb titers of 1∶4 to 1∶64 were obtained from six SIVmac239-infected rhesus macaques with NAb induction in the chronic phase for preparing the IgG inoculums for passive NAb immunization.
The four reference pools of plasma analyzed resulted in the identification of peptides shown in Figure 3a.
This can be largely avoided by using pools of plasma where these alloantigens and alloantibodies tend to neutralise each other.
Currently, three pools of plasma circulating miRNAs have been identified, that is, microparticle- (MP-) associated, high density lipoprotein- (HDL-) associated, and exosome-associated miRNAs [ 77].
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The superinfecting variants did not appear to be inherently neutralization resistant, as measured against a pool of plasma from unrelated HIV-infected individuals.
A total of 5 randomized, double-blind trials in patients with hypercholesterolemia were prospectively designed to allow pooling of plasma lipid data after 12 weeks of treatment.
Furthermore, a quality control (QC) sample was prepared by pooling of plasma from all subjects.
A pool of plasma samples from unexposed Danish women was used as a negative control.
A human anti-AMA1 standard plasma was made using a pool of plasma from 3 individuals receiving AMA1-C1 inmunization in a US vaccine trial (manuscript in preparation).
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