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Therefore, pooling of study data was not feasible and a meta-analysis was not possible.
A need for pooling of study results was predicted based on sample size calculations published by Lubin et al. in 1990 [ 25].
We were also unable to obtain additional data that would have enhanced pooling of study results despite multiple attempts to contact authors and the manufacturer of doxazosin (Pfizer Pharmaceuticals, New York, NY, USA).
Although pooling of study drugs may have overlooked variation in associations with mortality across classes, subgroup analyses indicated statistically significant associations (and dose-response effects) between mortality and all three classes of study drug.
Finally, because of the various outcome measures, different settings, interventions and populations, this systematic review did not allow for the pooling of study results to do a meta-analysis.
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Several guidelines have been published on pooling of classical epidemiological studies, but no information is available on pooling of studies involving biological markers.
The within-cluster concordance probability can be estimated by pooling cluster-specific concordance probability estimates (e.g. c-indexes) with a meta-analysis, similar to pooling of study-specific treatment effect estimates.
Pooling of studies stratified by dose may partially explain this heterogeneity.
For each of the steps involving pooling of studies, standard SROC (summary receiver operating characteristic) methods were used to pool individual study results[ 22].
For tests of HE4, the chemilumenesence immunoassays were more sensitive than the specified EIAs, thus bias might be introduced into pooling of studies.
A likelihood ratio test comparing models with and without random effects for exposure did not detect heterogeneity (P=0.201), supporting the pooling of studies.
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