Pooling of data from two randomized, double-blind, international studies (Breedt et al. 2005; Sacchidanand et al. 2005) in a modified ITT population of 1116 patients with complicated SSSIs showed no difference in length of hospital stay between patients receiving tigecycline and those receiving vancomycin/aztreonam (Mallick & Solomon 2005).
The strengths of this review include the relatively broad scope of interventions examined, the use of systematic search strategies, duplicate reviews and duplicate abstraction of data, and the use of a Bayesian meta-analysis model designed for pooling of data from individually and cluster-randomized trials, and the examination of a clinically important outcome.
The pooling of data from all patients participating in four high-quality randomized clinical trials with similar treatment and follow-up protocols offers a unique opportunity to assess the influence of BMI on clinical outcomes while minimizing unexplained variability commonly found in observational studies.
Pooling of data from overly dissimilar investigations should be avoided.
Much debate exists whether linezolid should be considered the drug of choice for MRSA pneumonia on the basis of two retrospective analyses of pooled data from randomized trials comparing linezolid and vancomycin for nosocomial pneumonia [ 50, 51].
Therefore, we conducted a systematic review and meta-analysis of pooled data from randomized controlled trials to evaluate the possible effect of omega-3 facid acid supplementation on cancer incidence, nonvascular death, and total mortality.
A meta-analysis of these studies that pooled data from randomized clinical trials registered up to April 2011 (including more than 20,000 subjects) showed that for all A(H1N1 2009 split/subunit inactivated vaccines, a course of two doses was highly immunogenic and fulfilled the seroconversion criteria.
In it, researchers pooled data from randomized trials of ginger and other common remedies for morning sickness, focusing on studies involving women in their first 20 weeks of pregnancy, when vomiting is most common.
Researchers at Drexel University pooled data from randomized trials of both music medicine, in which recordings simply are played for patients, and music therapy, in which trained therapists use music to assess and treat patients.
