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4 15 Network meta-analyses are an extension of traditional pairwise meta-analyses that enable the simultaneous pooling of data from clinical trials comparing at least two treatments and strengthen the inference on the relative efficacy of each treatment by including both direct and indirect information.
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We used metformin monotherapy as a common reference group, in contrast with the meta-analyses of data from clinical trials that pooled results across studies with varying drug and non-drug reference groups, introducing possible heterogeneity into those analyses.
The sharing of content models as demonstrated in this paper is an important step in itself but also of course an important step towards the ultimate goal of sharing patient specific clinical data – for direct patient care and for research and quality management that may require the pooling of data from several clinical settings.
A limitation of this trial is the pooling of data from controlled (with 24-week uncontrolled extensions) and uncontrolled clinical trials.
Pooling of data from overly dissimilar investigations should be avoided.
A clinical ontology for TBI in the era of the electronic medical record would facilitate the collection and pooling of data from multiple heath care facilities across various medical professions and would accelerate the understanding of cervical spine management strategies.
Similarly, there are issues surrounding quality assessment and the pooling of data from different data sources.
Meta-analysis incorporates statistical approaches to pool aggregate data from clinical trials into a summary effect measure [ 2].
Pooled data from clinical studies of DCV + ASV for chronic HCV GT-1b infection show that the most significant baseline correlate of SVR so far observed is the presence of pre-therapy DCV RAPs at NS5A amino acids L31 and/or Y93H.
The European Medicines Agency's Policy 070 on publication and access to clinical trial data will definitively help in that regard by creating the opportunity for scientists to access pools of individual-level data from clinical trials (http://www.ema.europa.eu/docs/en_GB/document_library/Other/2013/06/WC500144730.pdf).
Analysis of pooled data from 20 clinical trials in patients with T2DM suggests that saxagliptin is not associated with an increased CV risk.
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