Chondrocytes, whether bovine or human, were studied and compared from individual donors, in all experiments (that is, there was no pooling of cells from different donors).
By analyzing a pool of cell images, we observed that most CCR5 receptors appeared as clusters on the cell surfaces.
However, most investigators who conduct research with HESCs obtain them from an existing pool of cell lines and play no role in their derivation.
However, additional mutations, activation of inflammatory pathways or changes in the microenvironment were able to increase the pool of cell of origin to non-stem cells.
The microarray community might settle on RNA from a pool of cell lines of different cell types, or, even better, from pools of primary cell cultures that exhibit broadly diverse gene expression patterns.
Once the treatment is stopped, this remaining pool of cells can grow to repopulate the tumour.
For reference, that means if you're trying to modify cells, you've got a pool of cells, and some fraction of those get modified correctly.
Importantly, hierarchical tissue organization, with a few stem cells at the top of the hierarchy, would reduce the pool of cells most susceptible to oncogenic mutations.
Cardiac fibroblasts form one of the largest pools of cells in the heart and contribute to the normal structure and function of the myocardium (Souders et al., 2009).
Thus, the results of this part of research suggest that CSCs are mainly present in the pool of cells with CD44+ phenotype.
