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There was significant heterogeneity in the outcome of duration of antibiotic treatment between the pooled studies.
Subanalyses pooled studies by drug type and a meta-regression was performed to determine the effect of underlying patient risk factors on the efficacy of a single dose of IVC.
We pooled studies in which CV patients were compared with non-diseased controls.
We pooled studies using both fixed effect and random effects models.
We pooled studies from different populations, which usually resulted in non-ignorable errors on total effects.
Firstly, we pooled studies with both deep vein thrombosis and pulmonary embolism under the umbrella diagnosis of acute venous thromboembolism.
We pooled studies with the same thresholds for the reference and index tests and included them in a meta-analysis.
However, it should be noted that the majority of risk estimates were obtained from meta-analyses, pooled studies or reviews.
The effect was similar when we pooled studies that compared detoxification with no treatment only (1.66, 1.04 to 2.66; P=0.035; n=3 studies).
In sipuleucel-T treated subjects, a positive correlation was observed between OS and cumulative APC activation, APC count, and TNC count (pooled studies; Fig. 5).
Combined studies (pooled studies and meta-analyses) were thus usually the first choice if available, with UK studies added if necessary.
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