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The supplementary figure and table provide examples of reviews where the review did not specifically evaluate harm outcomes, the single primary harm outcome was clear from the review, the single primary harm outcome had to be chosen by the reviewer or pharmacological expert, and only pooled harms were specified.
16 It was not feasible to assess outcome reporting bias in reviews that dealt with only pooled harms because there would be no way to assess whether specific harms may have been excluded from the eligible studies when calculating "all harms".
For multicentre studies, procedures and timing should be outlined for central collection, evaluation, and reporting of pooled harms data.
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Accordingly, we agree with general arguments that disturbances increase the chance of immigration by species with various niches from the regional species pool (Sousa 1984; Myers and Harms 2011), and stochastic immigration history could obscure the explicit community assembly rules (Chase 2010).
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In France, government investigators have accused Servier of licensing Mediator as a diabetes drug to avoid scrutiny, but urging doctors to prescribe the pills as a diet aid to bolster sales — a practice that greatly expanded the pool of those potentially harmed by the drug.
Similarly, some nonindependence among pools will likely not harm the quality of inference under the model.
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CEO of Professional Science Editing for Scientists @ prosciediting.com