The within contemporary group minor allele frequency for pooled data was estimated as the mean of the allele frequencies of the pools, weighted by the number of individuals in each pool.
Each of the methods provides three different estimators namely, pooled, pooled weighted and grouped mean.
By allowing heterogenous long run variance, Mark and Sul [44, 45] developed pooled weighted DOLS.
The pooled weighted MD for the amount of blood transfusion per patient between TXA group and placebo group is -234.61 ml (95% CI: -383.23 to -85.99 ml).
Stata V.12.0 (serial no. 40120519635) will be used to calculate pooled ORs and 95% CIs for dichotomous variables and pooled weighted mean differences (WMDs) and 95% CIs for continuous variables.
Review Manager 5.0.22 (The Cochrane Collaboration, Oxford, England) was used to calculate pooled risk ratios (RRs) for dichotomous outcomes and pooled weighted mean differences (WMDs) for continuous outcomes, both with 95% confidence intervals (CIs) were calculated.
In addition, NAMCS data from the 1997, 1998, and 1999 databases [ 27- 29, 35] were pooled and weighted by patient visit weights as described in the National Ambulatory Medical Care Survey Data File Documentation [ 36].
In order to allow different long run variances across the cross section for heterogeneous panels, Pedroni [41] and Kao and Chiang [42] proposed pooled weighted FMOLS.
Then, we measured the pooled weighted effect size (weighted by the inverse variance of each study) using the random and fixed effect models.
Pooled weighted estimates for effect size and regression parameters were calculated leaving out one study at a time, and then compared to identify influential studies.
If the HES groups or control groups included more than one group, the respective data were pooled (weighted estimate) according to the Cochrane Handbook (7.7.3.8 section) [ 16].
