Sentence examples for pool of iron from inspiring English sources

In this way, the labile pool of iron can be quantified.

Various cell types contain a transient cytosolic pool of iron, presumably bound to low-molecular-mass intracellular chelates, such as citrate, various peptides, ATP, AMP or pyrophosphate.

The largest pool of iron in mammals is associated with heme and is required for oxygen transport in haemoglobin, oxygen storage in myoglobin, and electron transport for cytochrome function in mitochondrial respiration.

While this technique is still in its infancy, some groups have already demonstrated the ability to transfect cells with genes coding for heavy- and light-chain ferritin which is recognized as a storage pool of iron [ 35].

However, overexpression of ferritin also resulted in degeneration of these cells that was associated with aging (Kaur et al., 2007), and the degeneration was likely related to an increase in the labile pool of iron (Kaur et al., 2009).

An uncontrolled rise in intracellular iron may lead to the formation of a low molecular weight pool of iron potentially able to convert O2- and H2O2 into highly reactive OH radicals or ferryl ions.

Based on the rate-limiting, Fe(II) and NO2– dependent first reaction step (eq 2), a plausible scheme for the overall reaction kinetics is a second-order rate expression with overall rate constant kapp in analogy with oxidation of Fe(II) and Mn II) by O2 7 8where Fe(II) comprises the total pool of ferrous iron (free Fe2+ as well as all complexed Fe(II)).

Concurrently, production of non-essential proteins that use iron is inhibited, which increases the pool of free iron in the cell [ 10].

However, iron is toxic and leads to the production of free radicals via Fenton's reaction; thus, iron is generally bound to or forms part of proteins, and a less significant labile, low-molecular-mass pool of intracellular iron exists [ 22].

Figure 4a shows that after an iron influx pulse, iron is initially more abundant in the cLIP and it is quickly taken-up to produce an abundant initial pool of low iron content ferritins, because empty ferritin protein cages use their multiple active sites (pores) to capture ferrous irons (2/pore), creating an initial mineral core.

An alternative explanation is that a diminished cytosolic pool of bioavailable iron in sod1Δ mutant (De Freitas et al., 2000; Srinivasan et al., 2000) may impair Fe-S assembly in Pri2.