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In addition, natural selection may have operated at unequal intensities in different environments (e.g. in regions characterized by different levels of pathogen richness or prevalence of specific diseases), leaving heterogeneous signals in the genetic pool of human populations.
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Genetic structure of human populations.
The demographic structure of human populations has changed dramatically over the last 200 years, resulting in major changes in the size and composition of gene pools.
How did you pick the subject of human population?
We used human population pressure instead of human population density in each model.
A pool of human blood serum from healthy persons, used as control, was obtained commercially (Sigma).
(A) The demographic history of three human populations.
To detect differences in baseline tolerance across genes, we first needed a pool of nsSNVs that occur naturally across human populations.
We hypothesized that we could use the pool of nsSNVs that occur naturally in human populations to assess gene tolerance to perturbing nsSNVs.
Therefore, the presence of pathogens in human populations has left a strong mark and the differences between ancient and present gene pools can elucidate the course of major epidemics and help resolve any doubts about the time of disease origin.
Repeats mapping to the same position of the reference sequence were grouped among different individuals to collect population-wide repeat-number polymorphism at that locus (we pooled data from the four human populations for this analysis).
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